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KMID : 1149220080160020145
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Korean Journal of Oriental Medical Prescription
2008 Volume.16 No. 2 p.145 ~ p.153
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Chromosomalanomaly test of Sipjeondaebo-tang extract using the Chiness hamster lung
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Ma Jin-Yeul
Hwang Dae-Sun
Lee Nam-Hun
Ha Hye-Kyung
Yu Young-Beob
Shin Hyun-Kyu
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Abstract
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Objectives : This study was to assessment the toxicity of Sipjeondaebo-tang(Shiquan dabu-decoction) by Chromosomalanomaly test.
Methods : Sipjeondaebo-tang(Shiquan dabu-decoction) water-extract in vivo Chromosomalanomaly test was performed using chiness hamster lung cell line.
Results : Sipjeondaebo-tang water extract was negative in Chromosomalanomaly test at the doses of 0, 625, 1250 and at 6h and 24h.(S9- fraction). Chromosomalanomaly test(S+fraction) was also negative at the doses of 0, 1250, 2500 and .
Conclusions : It was concluded that Sipjeondaebo-tang extract did not induce Chromosomalanomaly in the chiness hamster lung cell.
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KEYWORD
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Sipjeondaebo-tang, Shiquan dabu-decoction, Chromosomalanomaly, -S9 Mix, +S9
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